TDHU, acid
TDHU, acid is a dihydropyrimidinecereblon ligand that contains an E3 ligase ligand and a benzoic acid linker. tDHU, acid can be used as an E3 ubiquitin ligase ligand-Linker conjugate for the development of PROTACs[1].
Product Specifications
CAS Number
[2377643-37-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tdhu-acid.html
Purity
98.83
Solubility
DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O
Molecular Formula
C12H12N2O4
Molecular Weight
248.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Novartis AG, et al. Preparation of dihydropyrimidine derivatives as bifunctional degraders for the treatment and prophylaxis of target protein-mediated diseases. World Intellectual Property Organization, WO2021053495 A1 2021-03-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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