GRB2 Recombinant Rabbit Monoclonal Antibody [JE49-73]
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Growth factor receptor-bound protein 2 Adapter protein GRB2 Protein Ash SH2/SH3 adapter GRB2 GRB2 ASH
Swiss Prot
P62993 Human, Q60631 Mouse, P62994 Rat
Cellular Locus
Cytoplasm. Endosome. Golgi apparatus. Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Monkey
Immunogen
Recombinant protein within Human GRB2 aa 1-100 / 217.
Isotype
IgG
Clone
JE49-73
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:100 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 25 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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