What is the catalog number for Maculosin?

The catalog number for Maculosin is HY-P1940.

What sizes are available for Maculosin?

Maculosin is available in the following size(s): 5 mg, 10 mg.

How many pack sizes does Maculosin come in?

Maculosin is available in 2 different pack sizes.

Is Maculosin in stock?

Maculosin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Maculosin?

Maculosin is manufactured by QuantiMol.

What is the estimated delivery time for Maculosin?

Estimated delivery time for Maculosin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Maculosin?

The safety data sheet for Maculosin is available here: http://file.medchemexpress.com/batch_PDF/HY-P1940/Maculosin-SDS-MedChemExpress.pdf.

Maculosin

Maculosin (Cyclo (Tyr-Pro) ) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties[1][2][3][4][5][6][7][8][9].Maculosin (Cyclo (Tyr-Pro) ) is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication. Maculosin also acts as a signaling molecule regulating virulence gene expression. Maculosin shows antimicrobial, antifungal, antioxidant and anti-cancer properties[1][2][3][4][5][6][7][8][9].

Product Specifications

CAS Number

4549-02-4

Product Name Alternative

Cyclo (Tyr-Pro)

UNSPSC

12352209

Hazard Statement

H301, H311, H331, H371

Target

Bacterial; Endogenous Metabolite; Fungal

Type

Peptides

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/maculosin.html

Purity

99.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C=C1)C[C@@H]2NC([C@]3([H])CCCN3C2=O)=O

Molecular Formula

C14H16N2O3

Molecular Weight

260.29

Precautions

H301, H311, H331, H371

References & Citations

[1]Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo (Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9 (1) :1606.|[2]Stierle AC, et al. Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Proc Natl Acad Sci U S A. 1988 Nov;85 (21) :8008-11.|[3]Paudel B, et al. Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18. Pharm Biol. 2021 Dec;59 (1) :933-936. |[4]Puopolo G, et al. Lysobacter capsici AZ78 produces cyclo (L-Pro-L-Tyr), a 2,5-diketopiperazine with toxic activity against sporangia of Phytophthora infestans and Plasmopara viticola. J Appl Microbiol. 2014 Oct;117 (4) :1168-80.|[5]Wattana-Amorn P, et al. Antibacterial activity of cyclo (L-Pro-L-Tyr) and cyclo (D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria. Nat Prod Res. 2016 Sep;30 (17) :1980-3. |[6]Cain CC, et al. Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator. Antimicrob Agents Chemother. 2003 Jul;47 (7) :2113-7.|[7]Driche EH, et al. A New Saharan Strain of Streptomyces sp. GSB-11 Produces Maculosin and N-acetyltyramine Active Against Multidrug-Resistant Pathogenic Bacteria. Curr Microbiol. 2022 Aug 24;79 (10) :298.|[8]Wang X, et al. Analysis of the Antioxidant Composition of Low Molecular Weight Metabolites from the Agarolytic Bacterium Alteromonas macleodii QZ9-9: Possibilities for High-Added Value Utilization of Macroalgae. Antioxidants (Basel) . 2022 Oct 3;11 (10) :1977.|[9]Wang Y, et al. Developments around the bioactive diketopiperazines: a patent review. Expert Opin Ther Pat. 2013 Nov;23 (11) :1415-33.