Thalidomide-O-amido-C8-NH2 (hydrochloride)
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[2415263-07-7]
UNSPSC
12352005
Hazard Statement
H301-H312-H361
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-amido-c8-nh2-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl
Molecular Formula
C23H31ClN4O6
Molecular Weight
494.97
Precautions
P264-P270-P280-P302+P352-P330-P362+P364-P405-P501
References & Citations
[1]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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