CDK4 degrader 1
CDK4 degrader 1 (ML 1–71) is a molecular glue degrader that targets CDK4[1].
Product Specifications
UNSPSC
12352005
Target
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-degrader-1.html
Purity
99.83
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(S(=O)(C=C)=O)CC4)C=C3)N=C2N1C5CCCC5)N(C)C
Molecular Formula
C25H32N8O3S
Molecular Weight
524.64
References & Citations
[1]Lim M, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders[J]. ACS Central Science, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4
Available Sizes
Curated Selection
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