CB10-277
CB10-277 is a Dacarbazine analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma[1].
Product Specifications
CAS Number
7203-91-0
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
DNA Alkylator/Crosslinker; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cb10-277.html
Smiles
O=C(C1=CC=C(C=C1)/N=N/N(C)C)O
Molecular Formula
C9H11N3O2
Molecular Weight
193.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Siow Ming, et al. "In vivo depletion of O 6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue." Cancer chemotherapy and pharmacology 31 (1992) : 240-246.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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