Hcyb1
Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 has a highly selective inhibition of PDE2A (IC50=0.57 μM) and over 250-fold selectivity against other recombinant PDE family members. Hcyb1 produces neuroprotective and antidepressant‐like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling[1].
Product Specifications
CAS Number
2988566-71-6
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hcyb1.html
Purity
98.20
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1NC(CC2=CC=CC=C2)=NC3=C1N=CN3C(C)C4=C5C=CC=CC5=CC=C4
Molecular Formula
C24H20N4O
Molecular Weight
380.44
References & Citations
[1]Li Liu, et al. The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor. CNS Neurosci Ther. 2018 Jul;24 (7) :652-660.|[2]Meng-Jia Zhu, et al. Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior. Psychopharmacology (Berl) . 2020 Nov;237 (11) :3215-3224.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE2
Available Sizes
Frequently Asked Questions
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