Azacyclonol (hydrochloride)
Azacyclonol (γ-pipradol) hydrochloride is a compound with promising anticancer activity, showing effectiveness in inhibiting NOX-derived ROS in A549 human lung cancer cells. Azacyclonol hydrochloride exhibits enhanced proliferation inhibition against androgen-refractory cancer cell lines, specifically DU145 and PC-3. Azacyclonol hydrochloride demonstrates antitumor activity in DU145-xenografted chorioallantoic membrane tumor models. Azacyclonol hydrochloride also acts as a ligand for the M3 muscarinic acetylcholine receptor, which is overexpressed in ARPC. Azacyclonol hydrochloride effectively blocks carbachol-induced proliferation and NOX activity in DU145 cells. Azacyclonol hydrochloride can also be utilized for the treatment of chronic schizophrenia.
Product Specifications
CAS Number
1798-50-1
Product Name Alternative
γ-pipradol (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H319
Target
MAChR; NADPH Oxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azacyclonol-hydrochloride.html
Smiles
OC(C1=CC=CC=C1)(C2CCNCC2)C3=CC=CC=C3.Cl
Molecular Formula
C18H22ClNO
Molecular Weight
303.83
Precautions
P264-P270-P280-P305+P351+P338-P330-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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