Azacyclonol (hydrochloride)

Azacyclonol (γ-pipradol) hydrochloride is a compound with promising anticancer activity, showing effectiveness in inhibiting NOX-derived ROS in A549 human lung cancer cells. Azacyclonol hydrochloride exhibits enhanced proliferation inhibition against androgen-refractory cancer cell lines, specifically DU145 and PC-3. Azacyclonol hydrochloride demonstrates antitumor activity in DU145-xenografted chorioallantoic membrane tumor models. Azacyclonol hydrochloride also acts as a ligand for the M3 muscarinic acetylcholine receptor, which is overexpressed in ARPC. Azacyclonol hydrochloride effectively blocks carbachol-induced proliferation and NOX activity in DU145 cells. Azacyclonol hydrochloride can also be utilized for the treatment of chronic schizophrenia.

Product Specifications

CAS Number

[1798-50-1]

Product Name Alternative

γ-pipradol (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H319

Target

MAChR; NADPH Oxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azacyclonol-hydrochloride.html

Smiles

OC(C1=CC=CC=C1)(C2CCNCC2)C3=CC=CC=C3.Cl

Molecular Formula

C18H22ClNO

Molecular Weight

303.83

Precautions

P264-P270-P280-P305+P351+P338-P330-P501

References & Citations

[1]Synthesis and anticancer evaluation of 6-azacyclonol-2,4,6-trimethylpyridin-3-ol derivatives: M3 muscarinic acetylcholine receptor-mediated anticancer activity of a cyclohexyl derivative in androgen-refractory prostate cancer