Homocarnosine (TFA)

Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1]. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].

Product Specifications

CAS Number

[2991254-59-0]

Product Name Alternative

L-Homocarnosine (TFA)

UNSPSC

12352005

Target

Endogenous Metabolite; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/homocarnosine-tfa.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)F.O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O

Molecular Formula

C12H17F3N4O5

Molecular Weight

354.28

References & Citations

[1]Petroff OA, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998;44 (6) :948-952.|[2]Kumrungsee T, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020;52 (5) :743-753.