PROTAC ATR degrader-1

PROTAC ATR degrader-1 (compound ZS-7) is a potent PROTAC degrader of ataxia telangiectasia and Rad3-related (ATR), with DC50 of 0.53 μM. PROTAC ATR degrader-1 plays an importnt role in cancer research[1].

Product Specifications

CAS Number

[2925916-30-7]

UNSPSC

12352005

Target

ATM/ATR; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-atr-degrader-1.html

Purity

98.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1C2C(NC(CC2)=O)=O)C3=C(C=CC=C3C1=O)NC(CCCCCCCN4N=NC(CCC(N=[S@](C5(C6=CC(N7[C@@H](COCC7)C)=NC(C8=CC=NC9=C8C=CN9)=N6)CC5)(C)=O)=O)=C4)=O

Molecular Formula

C46H52N12O8S

Molecular Weight

933.05

References & Citations

[1]Lei Huang, et al. Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.Eur J Med Chem. 2024 Feb 1:267:116159.