PROTAC ATR degrader-1
PROTAC ATR degrader-1 (compound ZS-7) is a potent PROTAC degrader of ataxia telangiectasia and Rad3-related (ATR), with DC50 of 0.53 μM. PROTAC ATR degrader-1 plays an importnt role in cancer research[1].
Product Specifications
CAS Number
[2925916-30-7]
UNSPSC
12352005
Target
ATM/ATR; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-atr-degrader-1.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=C(C=CC=C3C1=O)NC(CCCCCCCN4N=NC(CCC(N=[S@](C5(C6=CC(N7[C@@H](COCC7)C)=NC(C8=CC=NC9=C8C=CN9)=N6)CC5)(C)=O)=O)=C4)=O
Molecular Formula
C46H52N12O8S
Molecular Weight
933.05
References & Citations
[1]Lei Huang, et al. Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.Eur J Med Chem. 2024 Feb 1:267:116159.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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