Didesmethylsibutramine (hydrochloride)

Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent) . Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2].

Product Specifications

CAS Number

[84484-78-6]

Product Name Alternative

BTS 54-505

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/didesmethylsibutramine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2(C(CC(C)C)N)CCC2)C=C1.Cl

Molecular Formula

C15H23Cl2N

Molecular Weight

288.26

Precautions

P261-P280-P302+P352

References & Citations

[1]Scott G, et al. The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. Br J Pharmacol. 1994 Jan;111 (1) :97-102.|[2]Liu YL, et al. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int J Obes Relat Metab Disord. 2002 Sep;26 (9) :1245-53.