IQ 1

IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP-mediated transcription and preventing conversion to β-catenin/p300-mediated transcription. IQ-1 regulates Wnt signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion[1].

Product Specifications

CAS Number

[331001-62-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/IQ-1.html

Purity

99.13

Solubility

DMSO : ≥ 33 mg/mL

Smiles

CC(C1=CC=C(/N=N/C(C(N)=O)=C2NC(C)(C)CC3=CC=CC=C3/2)C=C1)=O

Molecular Formula

C21H22N4O2

Molecular Weight

362.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Miyabayashi T, et al. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A. 2007 Mar 27;104 (13) :5668-73.