HPK1-IN-45
HPK1-IN-45 (Compound 3) is a HPK1 inhibitor, with an IC50 of 0.3 nM. HPK1-IN-45 inhibits SLP-76 phosphorylation (IC50 = 57.52 nM) and IL-2 release (IC50 = 38 nM) . HPK1-IN-45 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-45.html
Solubility
10 mM in DMSO
Smiles
CC1(C2=CC(N3CCOCC3)=CC=C2NC4=C1C=C(C5=C4C(NC=C5)=O)C6=CN=C7C(OC)=CC=CN67)C
Molecular Formula
C30H29N5O3
Molecular Weight
507.58
References & Citations
[1]Sun GL, et al. Hpk1 inhibitor, preparation method therefor, and use thereof. WO2024061345A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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