QC-01–175

QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397) ; Black: linker NH2-PEG3 (HY-W007545) ; Blue: ligand for E3 ligase Pomalidomide (HY-10984) ) [1][2].

Product Specifications

CAS Number

[2267290-96-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

PROTACs; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling; PROTAC

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/qc-01-175.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(C=C4)C(C=NC=C6)=C6N5

Molecular Formula

C33H34N6O7

Molecular Weight

626.66

Precautions

H315, H319, H320

References & Citations

[1]Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457.|[2]Tiziana Petrozziello, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan;59 (1) :683-702.