2-Hydroxybutyric acid

2-Hydroxybutyric acid (α-Hydroxybutyric acid) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite[1]. 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia[2][4]. 2-Hydroxybutyric acid prevents the acetaminophen (AP) -induced liver injury[3].

Product Specifications

CAS Number

[600-15-7]

Product Name Alternative

α-Hydroxybutyric acid

UNSPSC

12352211

Hazard Statement

H315, H318, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-hydroxybutyric-acid.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 50°C) |H2O : ≥ 300 mg/mL

Smiles

CCC(O)C(O)=O

Molecular Formula

C4H8O3

Molecular Weight

104.10

Precautions

H315, H318, H335

References & Citations

[1]Landaas S, et al. The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta. 1975 Jan 6;58 (1) :23-32.|[2]Shantavasinkul PC, et al., Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surg Obes Relat Dis. 2018 Aug;14 (8) :1126-1132.|[3]Zheng N, et al., Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. J Pharm Anal. 2020 Dec;10 (6) :560-570.|[4]Wang F, et al., Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia. Open Life Sci. 2023 Feb 28;18 (1) :20220572.