MCOPPB (trihydrochloride)

MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors. IC50 value: 10.07 (pKi) Target: nociceptin receptor MCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP) -receptor agonist with a pKi of 10.07 ± 0.01 for the human NOP receptor.

Product Specifications

CAS Number

[1108147-88-1]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mcoppb-trihydrochloride.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(N2CCC(N3C4=CC=CC=C4N=C3[C@H]5CNCCC5)CC2)CCCCCCC1.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C26H43Cl3N4

Molecular Weight

518.01

References & Citations

[1]Hayashi, Shigeo; Hirao, Akiko; Imai, Aki; Nakamura, Hiroshi; Murata, Yoshinori; Ohashi, Katsuyo; Nakata, Eriko. Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1- (1-Methylcyclooctyl) -4-piperidinyl]-2-[ (3R) -3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and  Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug. Journal of Medicinal Chemistry (2009), 52 (3), 610-625.|[2]Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E.Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1- (1-Methylcyclooctyl) -4-piperidinyl]-2-[ (3R) -3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.J Med Chem. 2009 Feb 12;52 (3) :610-25.|[3]Hirao A, Imai A, Sugie Y, Yamada Y, Hayashi S, Toide K.Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1- (1-methylcyclooctyl) -4-piperidinyl]-2-[ (3R) -3-piperidinyl]-1H-benzimidazole as an anxiolytic agent.J Pharmacol Sci. 2008 Mar;106 (3) :361-8. Epub 2008 Mar 5.