Poricoic acid A
Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin[1][2][3].
Product Specifications
Product Name Alternative
Poricoic acid A (F)
UNSPSC
12352211
Target
AMPK; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS) ; TGF-beta/Smad
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/poricoic-acid-a.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@@H](C(C)=C)[C@]3(C)CCC(O)=O)C
Molecular Formula
C31H46O5
Molecular Weight
498.69
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2995/Poricoic-acid-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2995/Poricoic-acid-A-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
CAS Number
[137551-38-3]
Available Sizes
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