Corylifol A
Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.
Product Specifications
CAS Number
[775351-88-7]
Product Name Alternative
Corylifol-A; Corylinin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STAT; UGT
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Corylifol-A.html
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)\C)=C2)=COC3=CC(O)=CC=C13
Molecular Formula
C25H26O4
Molecular Weight
390.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78 (9) :903-6.|[2]Kim DW, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29 (1) :59-63.|[3]Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106. d
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Curated Selection
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