Corylifol A

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

Product Specifications

CAS Number

[775351-88-7]

Product Name Alternative

Corylifol-A; Corylinin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

STAT; UGT

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Corylifol-A.html

Purity

99.90

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)\C)=C2)=COC3=CC(O)=CC=C13

Molecular Formula

C25H26O4

Molecular Weight

390.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78 (9) :903-6.|[2]Kim DW, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29 (1) :59-63.|[3]Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106. d