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ZG-2033

ZG-2033 (Compound 26) is an orally active HIF-2α agonist that demonstrates nanomolar activity in luciferase reporter gene assays (EC50 = 490 nM). ZG-2033 has the effect of alleviating anemia and exhibits synergistic action with AKB-6548 in anemia, and can be used in the study of renal anemia[1].

Product Specifications

CAS Number

2685739-28-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/zg-2033.html

Smiles

COC1=CC(OC)=CC(NC2=NSC3=CC=CC=C23)=C1

Molecular Formula

C15H14N2O2S

Molecular Weight

286.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Yu Y, et al. Discovery of a potent and orally bioavailable hypoxia-inducible factor 2α (HIF-2α) agonist and its synergistic therapy with prolyl hydroxylase inhibitors for the treatment of renal anemia[J]. Journal of Medicinal Chemistry, 2021, 64 (23) : 17384-17402.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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