Thiosemicarbazide

Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co (II) and Cu (I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals[1][2][3][1][2][3].

Product Specifications

CAS Number

[79-19-6]

UNSPSC

12352211

Hazard Statement

H300, H412

Target

Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Cancer; Infection; Others

Assay Protocol

https://www.medchemexpress.com/thiosemicarbazide.html

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NNC(N)=S

Molecular Formula

CH5N3S

Molecular Weight

91.14

Precautions

H300, H412

References & Citations

[1]Yamashita J. Susceptibility to thiosemicarbazide (an antagonist of vitamin B6), and phylogenetic and ontogenetic development of brain. J Nutr Sci Vitaminol (Tokyo) . 1974;20 (2) :113-9.|[2]Hamrani O, et al. Reaction of thiosemicarbazide with some divalent ions: Synthesis, characterization, molecular modeling, and evaluation of the catalytic and biological activity of the complexes[J]. Inorganic and Nano-Metal Chemistry, 2017, 47 (7) : 1070-1079.|[3]Kozyra P, et al. Potential Anticancer Agents against Melanoma Cells Based on an As-Synthesized Thiosemicarbazide Derivative. Biomolecules. 2022 Jan 18;12 (2) :151.