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Siglec-15, Mouse (Biotinylated, HEK293, His)

Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived Siglec-15 protein, expressed by HEK293 , with C-His labeled tag.

Product Specifications

Product Name Alternative

Siglec-15 Protein, Mouse (Biotinylated, HEK293, His), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/siglec-15-protein-mouse-biotinylated-hek293-his.html

Molecular Formula

620235 (Gene_ID) A7E1W8 (R24-T262) (Accession)

Molecular Weight

Approximately 35-43 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Angata T. Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases. J Biomed Sci. 2020 Jan 3;27 (1) :10.|[2]Wang J, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nat Med. 2019 Apr;25 (4) :656-666.|[3]Kang FB, et al. The diverse functions of Siglec-15 in bone remodeling and antitumor responses. Pharmacol Res. 2020 May;155:104728.|[4]Rashid S, et al. Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer. J Cell Physiol. 2022 Mar;237 (3) :1711-1719.

Shipping Conditions

Dry ice.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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