Iturin A

Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity[1][2].

Product Specifications

CAS Number

[52229-90-0]

UNSPSC

12352209

Target

Apoptosis; Autophagy; Fungal; Reactive Oxygen Species (ROS)

Type

Peptides

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/iturin-a.html

Purity

98.53

Solubility

Ethanol : 5 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC(N)=O)C(N[C@H](CC1=CC=C(O)C=C1)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N2CCC[C@H]2C(N[C@H](CC(N)=O)C(N[C@@H](CO)C(N3)=O)=O)=O)=O)=O)=O)=O)C[C@@H]3CCCCCCCC[R]

References & Citations

[1]Gong AD, et al. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS One. 2015 Feb 17;10 (2) :e0116871.|[2]Zhao H, et al. Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo. AMB Express. 2021 May 10;11 (1) :67.