Lupanine (perchlorate)

Lupanine (D-Lupanine) perchlorate is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine perchlorate shows binding affinity for nicotinic receptor with a Ki value of 500 nM[1].

Product Specifications

CAS Number

[7400-11-5]

Product Name Alternative

D-Lupanine (perchlorate)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lupanine-perchlorate.html

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@]([C@](C3)([H])CN(CCCC4)[C@]4([H])[C@]3([H])C2)([H])CCC1.O=Cl(=O)(O)=O

Molecular Formula

C15H25ClN2O5

Molecular Weight

348.82

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]K Yovo, et al. Comparative pharmacological study of sparteine and its ketonic derivative lupanine from seeds of Lupinus albus. Planta Med. 1984 Oct;50 (5) :420-4.|[2]Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.