GNE-317

GNE-317 is a PI3K/mTOR inhibitor, is able to cross the blood-brain barrier (BBB) .

Product Specifications

CAS Number

[1394076-92-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-317.html

Concentration

10mM

Purity

98.76

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(C5(OC)COC5)S4)=N2)C=N1

Molecular Formula

C19H22N6O3S

Molecular Weight

414.48

Precautions

H315, H319, H320

References & Citations

[1]Salphati L, et al. Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging. Drug Metab Dispos. 2014 Jul;42 (7) :1110-6.|[2]Becker CM, et al. Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma. Neuro Oncol. 2015 Sep;17 (9) :1210-9.