GNE-317
GNE-317 is a PI3K/mTOR inhibitor, is able to cross the blood-brain barrier (BBB) .
Product Specifications
CAS Number
[1394076-92-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-317.html
Concentration
10mM
Purity
98.76
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(C5(OC)COC5)S4)=N2)C=N1
Molecular Formula
C19H22N6O3S
Molecular Weight
414.48
Precautions
H315, H319, H320
References & Citations
[1]Salphati L, et al. Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging. Drug Metab Dispos. 2014 Jul;42 (7) :1110-6.|[2]Becker CM, et al. Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma. Neuro Oncol. 2015 Sep;17 (9) :1210-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3K
Available Sizes
Curated Selection
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