Lyn peptide inhibitor

Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders[1].

Product Specifications

CAS Number

[222018-18-0]

UNSPSC

12352211

Target

Interleukin Related; Src

Type

Reference compound

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lyn-peptide-inhibitor.html

Purity

99.35

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CNC([C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CC2=CC=C(C=C2)O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N3[C@@H](CCC3)C(N[C@@H](CC(N)=O)C(N4[C@@H](CCC4)C(N)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O

Molecular Formula

C115H184N30O24

Molecular Weight

2370.88

References & Citations

[1]T Adachi, et al. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162 (3) :1496-501.|[2]T Adachi, et al. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J Immunol. 1999 Jul 15;163 (2) :939-46.