N-Acetylcarnosine

N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic agent in human cataracts[1].

Product Specifications

CAS Number

[56353-15-2]

Product Name Alternative

N-Acetyl-L-carnosine

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate; Endogenous Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-acetylcarnosine.html

Concentration

10mM

Purity

99.92

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

OC([C@@H](NC(CCNC(C)=O)=O)CC1=CNC=N1)=O

Molecular Formula

C11H16N4O4

Molecular Weight

268.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Babizhayev MA, et al. N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts. Peptides. 2001 Jun;22 (6) :979-94.|[2]Dubois VD, et al. N-acetylcarnosine (NAC) drops for age-related cataract. Cochrane Database Syst Rev. 2017 Feb 28;2:CD009493.|[3]Babizhayev MA, et al. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases. Drug Metabol Drug Interact. 2009;24 (2-4) :275-323.