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(-) -Epicatechin gallate

(-) -Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1][2]. (-) -Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-) -Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells[3].

Product Specifications

CAS Number

1257-08-5

Product Name Alternative

Epicatechin gallate; ECG; (-) -Epicatechin 3-O-gallate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; COX; GLUT; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/_-_-Epicatechin-gallate.html

Purity

99.61

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4

Molecular Formula

C22H18O10

Molecular Weight

442.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Takizawa Y, et al. Pharmacokinetics of (-) -epicatechin-3-O-gallate, an active component of Onpi-to, in rats. Biol Pharm Bull. 2003 May;26 (5) :608-12.|[3]Tripp J, et al. Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators. Sci Rep. 2017 Jul 24;7 (1) :6197.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

Phase 4

Isoform

COX-1; GLUT1

Available Sizes

Frequently Asked Questions

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