Taxinine B
Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl2-induced depolymerization of microtubule. Taxinine B is useful for overcoming multidrug resistance in tumor cells[1].
Product Specifications
CAS Number
18457-44-8
Product Name Alternative
Taxinin B
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taxinine-b.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H](C1=C)C[C@H](OC(C)=O)[C@]([C@@H](OC(C)=O)[C@H](OC(C)=O)C2=C3C)(C)[C@]1([H])[C@H](OC(C)=O)[C@](C2(C)C)([H])CC3=O)/C=C/C4=CC=CC=C4
Molecular Formula
C37H44O11
Molecular Weight
664.74
References & Citations
[1]Juníchi Kobayashi, et al. Taxuspines A ∼ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. Tetrahedron. 1994. 50 (25), 7401-7416.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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