Archangelicin

Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC50 >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC50 of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory[1][2][3].

Product Specifications

CAS Number

[2607-56-9]

UNSPSC

12352005

Target

Nuclear Factor of activated T Cells (NFAT) ; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/archangelicin.html

Smiles

C/C=C(C)\C(O[C@H]1[C@@H](C(OC(/C(C)=C\C)=O)(C)C)OC(C=C2)=C1C(O3)=C2C=CC3=O)=O

Molecular Formula

C24H26O7

Molecular Weight

426.46

References & Citations

[1]Okuyama T, et al., Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 1991 Jun;57 (3) :242-6.|[2]Thastrup O, et al., Inhibition of human platelet aggregation by dihydropyrano- and dihydrofuranocoumarins, a new class of cAMP-phosphodiesterase inhibitors. Biochem Pharmacol. 1985 Jun 15;34 (12) :2137-40.|[3]Nagasawa A, et al. Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway[J]. Natural Product Communications, 2014, 9 (12) : 1934578X1400901218.