Tetomilast

Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD) .

Product Specifications

CAS Number

[145739-56-6]

Product Name Alternative

OPC-6535

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tetomilast.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

CCOC1=C(OCC)C=CC(C2=NC(C3=CC=CC(C(O)=O)=N3)=CS2)=C1

Molecular Formula

C19H18N2O4S

Molecular Weight

370.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Ichikawa H, Okamoto S, Kamada N, et al. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. Inflamm Bowel Dis. 2008;14 (11) :1483-1490.