Diquat (dibromide)

Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[85-00-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H317, H319, H330, H335, H372, H410

Target

Autophagy; Herbicide; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/diquat-dibromide.html

Purity

99.94

Solubility

H2O : 5.83 mg/mL (ultrasonic)

Smiles

[N+]12=CC=CC=C1C3=[N+](CC2)C=CC=C3.[Br-].[Br-]

Molecular Formula

C12H12Br2N2

Molecular Weight

344.05

Precautions

H302, H315, H317, H319, H330, H335, H372, H410

References & Citations

[1]Acar A. In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28 (34) :47550-47561. |[2]Moreland D E. Mechanisms of action of herbicides. 1980.|[3]Cao S, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 2018 May 4;96 (5) :1795-1805.|[4]Singh P, et al. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis. 2017;2017:2643587.|[5]Tomášek O, et al. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling. Sci Rep. 2016 Mar 22;6:23546.|[6]Nisar R, et al. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015 Oct;89 (10) :1811-25.|[7]Zhang JQ, et al. Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice. PLoS One. 2016 Jan 19;11 (1) :e0147075.|[8]Karuppagounder SS, et al. Investigate the chronic neurotoxic effects of diquat. Neurochem Res. 2012 May;37 (5) :1102-11.