Onzigolide
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors[1][2].
Product Specifications
CAS Number
[778630-77-6]
Product Name Alternative
BIM-23A760; TBR-760
UNSPSC
12352209
Target
Dopamine Receptor; Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/onzigolide.html
Solubility
10 mM in DMSO
Smiles
CCCN1[C@@]2([H])[C@@](C[C@H](C1)CSCC(N[C@H](CCCCNC(CSC[C@@H]3C[C@]4([H])C5=CC=CC6=C5C(C[C@@]4([H])N(C3)CCC)=CN6)=O)C(N[C@@H]7C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC7)C(N[C@H](C(N)=O)[C@H](O)C)=O)=O)CC)=O)CCCCN)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CC=C(C=C%10)O)=O)=O)=O)([H])C%11=CC=CC%12=C%11C(C2)=CN%12
Molecular Formula
C86H116N16O12S4
Molecular Weight
1694.20
References & Citations
[1]Halem HA, et al. TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161 (8) :bqaa101.|[2]Cuny T, et al. Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells. Pituitary. 2021 Jun;24 (3) :351-358.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3294/Onzigolide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3294/
Scientific Category
Peptides
Clinical Information
Phase 2
Isoform
SSTR2
Curated Selection
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