GNE-3500
GNE-3500 is a selective, orally active antagonist for Retinoic Acid Receptor-Related Orphan Receptor C (RORc, also known as RORγ or NR1F3) with an EC50 of 12 nM. GNE-3500 exhibits good pharmacokinetic characteristics in rats[1].
Product Specifications
CAS Number
1537859-24-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gne-3500.html
Purity
98.90
Smiles
FC1=CC(N2CCN(C(C)=O)CC2)=CC=C1CN3[C@@H](C)CC[C@H](C4=CC=CC=C4)S3(=O)=O
Molecular Formula
C24H30FN3O3S
Molecular Weight
459.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Fauber BP, et al., Discovery of 1-{4-[3-fluoro-4- ((3s,6r) -3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl) -phenyl]-piperazin-1-yl}-ethanone (GNE-3500) : a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist. J Med Chem. 2015 Jul 9;58 (13) :5308-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ
Available Sizes
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