AH2-14c
AH2-14c is an inhibitor for DNA demethylase ALKBH2. AH2-14c inhibits the cell viability (IC50 is 4.56 µM) and migration of GBM U87. AH2-14c regulates the expression of apoptosis-related genes, and induces apoptosis in GBM U87 cell[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ah2-14c.html
Purity
98.01
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
CC(C)(C)C(NC(C1=CC=C(N2N=CC(C(OCC)=O)=C2)N=C1)=O)C3=CC=CC=C3
Molecular Formula
C23H26N4O3
Molecular Weight
406.48
References & Citations
[1]Xu K, et al., Discovery and structure-activity relationship study of nicotinamide derivatives as DNA demethylase ALKBH2 inhibitors. Eur J Med Chem. 2025 Jan 15;282:117054.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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