[Leu144]-PLP (139-151)

[Leu144]-PLP (139-151) (L144-PLP (139-151) ) is a peptide ligand of T cell receptor. [Leu144]-PLP (139-151) is a TCR antagonist for encephalitogenic Th1 clones, blocking their activation[1].

Product Specifications

CAS Number

[202462-61-1]

Product Name Alternative

L144-PLP (139-151)

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/leu144-plp-139-151.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CC1=CN=CN1)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C67H105N19O17

Molecular Weight

1448.67

References & Citations

[1]Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94 (17) :9279-84.