TP-2
TP-2, a caltrop-like multicationic small molecule, is an antidote that can completely neutralize both unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) . TP-2 is not only superior to protamine, has higher neutralization activity, but is also biocompatible[1].
Product Specifications
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tp-2.html
Solubility
10 mM in DMSO
Smiles
NCCOC1=C(C=CC(C2=CC=[N+](C=C2)CC3=CC=C(C(C4=CC=C(C=C4)C[N+]5=CC=C(C=C5)C6=CC(OCCN)=C(C=C6)OCCN)(C7=CC=C(C=C7)C[N+]8=CC=C(C=C8)C9=CC(OCCN)=C(C=C9)OCCN)C%10=CC=C(C=C%10)C[N+]%11=CC=C(C=C%11)C%12=CC(OCCN)=C(C=C%12)OCCN)C=C3)=C1)OCCN.[Cl-].[Cl-].[Cl-].[Cl-]
Molecular Formula
C89H100Cl4N12O8
Molecular Weight
1607.63
References & Citations
[1]Zong Y, et al. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo. J Med Chem. 2024 Feb 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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