(R) -CE3F4

(R) -CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM) . (R) -CE3F4 is more potent than racemic CE3F4 and (S) -CE3F4[1].

Product Specifications

CAS Number

[1593478-56-8]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-ce3f4.html

Purity

99.3

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=CN1[C@H](C)CCC2=C1C=C(Br)C(F)=C2Br

Molecular Formula

C11H10Br2FNO

Molecular Weight

351.01

References & Citations

[1]Courilleau D, et al. The (R) -enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1) . Biochem Biophys Res Commun. 2013 Oct 25;440 (3) :443-8.