(R)-CE3F4
Product Specifications
UNSPSC Description
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4[1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-ce3f4.html
Purity
99.0
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=CN1[C@H](C)CCC2=C1C=C(Br)C(F)=C2Br
Molecular Weight
351.01
References & Citations
[1]Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108539A/R-CE3F4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108539A/R-CE3F4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1593478-56-8
Available Sizes
Curated Selection
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