(R) -CE3F4
(R) -CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM) . (R) -CE3F4 is more potent than racemic CE3F4 and (S) -CE3F4[1].
Product Specifications
CAS Number
[1593478-56-8]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-ce3f4.html
Purity
99.3
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=CN1[C@H](C)CCC2=C1C=C(Br)C(F)=C2Br
Molecular Formula
C11H10Br2FNO
Molecular Weight
351.01
References & Citations
[1]Courilleau D, et al. The (R) -enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1) . Biochem Biophys Res Commun. 2013 Oct 25;440 (3) :443-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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