Funalenone

Funalenone, a phenalene compound isolated from mycelium of Aspergillus niger FO-5904, acts as an inhibitor of type I collagenase (MMP-1). Funalenone inhibits 50% of type I collagenase activity at a concentration of 170 µM but inhibits 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 µM.