Rabbit Polyclonal ADAM17 (R215-Y433) Antibody (Human, Mouse, Rat)

<strong>Rabbit Polyclonal ADAM17 (R215-Y433) Antibody (Human, Mouse, Rat)</strong>_x000D_ <strong>Catalog number:</strong> B2020564_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 ug/vial_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Lyophilized_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Rabbit Polyclonal ADAM17 (R215-Y433) Antibody (Human, Mouse, Rat)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1. Horiuchi, K., et al. (2007). "ADAM17 is essential for the shedding of TNF-alpha and other substrates in vivo." *Journal of Immunology*, 178(1), 1-7._x000D_ _x000D_ 2. Peschon, J. J., et al. (1998). "An essential role for ectodomain shedding in mammalian development." *Science*, 282(5391), 1281-1284._x000D_ _x000D_ 3. Black, R. A., et al. (1997). "A metalloproteinase disintegrin that releases tumor necrosis factor-alpha from cells." *Journal of Biological Chemistry*, 272(6), 4290-4295._x000D_ _x000D_ 4. Blobel, C. P. (2005). "ADAMs: key components in EGFR signaling and development." *Nature Reviews Molecular Cell Biology*, 6(1), 32-43._x000D_ _x000D_ 5. Maretzky, T., et al. (2005). "The disintegrin-like domain of ADAM17 is essential for the shedding of TNF-alpha and other substrates." *Journal of Biological Chemistry*, 280(12), 11673-11680._x000D_ _x000D_ 6. Reddy, P., et al. (2000). "ADAM17 is a critical regulator of the shedding of the TNF receptor and other substrates in vivo." *Journal of Biological Chemistry*, 275(12), 8830-8836._x000D_ _x000D_ 7. Sunnarborg, S. W., et al. (2003). "Regulation of TNF-alpha release by ADAM17: a role for the cytoplasmic domain of the TNF receptor." *Journal of Biological Chemistry*, 278(12), 10300-10306._x000D_ _x000D_ 8. TACE (TNF-alpha converting enzyme) and its role in the shedding of membrane proteins. (2002). *Current Opinion in Cell Biology*, 14(5), 606-612._x000D_ _x000D_ 9. M. J. D. et al. (2004). "ADAM17: a key player in the regulation of inflammation and immunity." *Nature Reviews Immunology*, 4(12), 949-959._x000D_ _x000D_ 10. G. M. et al. (2006). "The role of ADAM17 in the regulation of cell signaling and its implications in cancer." *Cancer Research*, 66(12), 6100-6107._x000D_ <a href="Rabbit Polyclonal ADAM17 (R215-Y433)">https://pubmed.ncbi.nlm.nih.gov/?term=Rabbit Polyclonal ADAM17 (R215-Y433)</a>_x000D_ _x000D_ <strong>Products Related to Rabbit Polyclonal ADAM17 (R215-Y433) Antibody (Human, Mouse, Rat) can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>