SMO-IN-5
SMO-IN-5 ((Compound 25 (B31) ) is a potent and competitive inhibitor of smoothened (SMO) that can inhibit Hedgehog (Hh) signaling. SMO-IN-5 interacts with Smo through hydrogen bonds, hydrophobic interactions, and electrostatic forces. SMO-IN-5 inhibits PC cell proliferation, migration, and induces apoptosis by suppressing Gli1 expression. SMO-IN-5 exhibits antitumor activity in pancreatic cancer.[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smo-in-5.html
Smiles
O=C(NC1=CC=C(CN(C)C)C=C1)C2=CC=C(NC3=NC=CC(C4=CC=CN=C4)=N3)C=C2
Molecular Formula
C25H24N6O
Molecular Weight
424.50
References & Citations
[1]Li H, et al. Synthesis of pyridyl pyrimidine hedgehog signaling pathway inhibitors and their antitumor activity in human pancreatic cancer. Eur J Med Chem. 2024 Oct 15;280:116961.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
HA723219 100 µL
Acetylcholinesterase Recombinant Rabbit monoclonal Antibody
Sign In for Pricing
View Details 
