SMO-IN-5
SMO-IN-5 ((Compound 25 (B31) ) is a potent and competitive inhibitor of smoothened (SMO) that can inhibit Hedgehog (Hh) signaling. SMO-IN-5 interacts with Smo through hydrogen bonds, hydrophobic interactions, and electrostatic forces. SMO-IN-5 inhibits PC cell proliferation, migration, and induces apoptosis by suppressing Gli1 expression. SMO-IN-5 exhibits antitumor activity in pancreatic cancer.[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smo-in-5.html
Smiles
O=C(NC1=CC=C(CN(C)C)C=C1)C2=CC=C(NC3=NC=CC(C4=CC=CN=C4)=N3)C=C2
Molecular Formula
C25H24N6O
Molecular Weight
424.50
References & Citations
[1]Li H, et al. Synthesis of pyridyl pyrimidine hedgehog signaling pathway inhibitors and their antitumor activity in human pancreatic cancer. Eur J Med Chem. 2024 Oct 15;280:116961.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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