Piezo1 agonist 1-d2
Piezo1 agonist 1-d2 (Compound 12a) is an agonist for Piezo1 with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates the Ca2+-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) . Piezo1 agonist 1-d2 ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model[1].
Product Specifications
CAS Number
3058199-62-2
UNSPSC
12352005
Target
ERK; Piezo Channel
Type
Isotope-Labeled Compounds
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
ClC1=C(C(Cl)=CC=C1)C([2H])(SC2=NN=C(S2)C3=CN=C(C=N3)NC[C@@H](C)O)[2H]
Molecular Formula
C16H13D2Cl2N5OS2
Molecular Weight
430.37
References & Citations
[1]Tang H, et al., Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl) pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis. J Med Chem. 2024 Nov 14;67 (21) :19837-19851.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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