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Piezo1 agonist 1-d2

Piezo1 agonist 1-d2 (Compound 12a) is an agonist for Piezo1 with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates the Ca2+-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) . Piezo1 agonist 1-d2 ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model[1].

Product Specifications

CAS Number

3058199-62-2

UNSPSC

12352005

Target

ERK; Piezo Channel

Type

Isotope-Labeled Compounds

Related Pathways

MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

ClC1=C(C(Cl)=CC=C1)C([2H])(SC2=NN=C(S2)C3=CN=C(C=N3)NC[C@@H](C)O)[2H]

Molecular Formula

C16H13D2Cl2N5OS2

Molecular Weight

430.37

References & Citations

[1]Tang H, et al., Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl) pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis. J Med Chem. 2024 Nov 14;67 (21) :19837-19851.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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