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DTAGV-1 (TFA)

DTAGV-1 TFA is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420) ; Black: Linker (HY-W012001) ; Blue: VHL Ligand (HY-112078) ; VHL Ligan+Linker (HY-173628A) ) [1]

Product Specifications

CAS Number

[2624313-15-9]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

FKBP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dtagv-1-tfa.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(C(F)(F)F)=O.O=C([C@H]1N(CCCC1)C([C@H](C2=CC(OC)=C(C(OC)=C2)OC)CC)=O)O[C@@H](C3=C(C=CC=C3)OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)CCC7=CC(OC)=C(C=C7)OC

Molecular Formula

C70H91F3N6O16S

Molecular Weight

1361.56

Precautions

H302, H312, H332

References & Citations

[1]Nabet B, et, al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

FKBP12

Citation 01

BioRxiv. 2025 July 08.|bioRxiv. 2025 March 03.|Mayo Clinic. 2025.|Sci Adv. 2025 Nov 28;11 (48) :eadz2345.|Nature. 2025 Feb;638 (8052) :1095-1103.

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