Nrf2 activator 18
Product Specifications
UNSPSC Description
Nrf2 activator 18 (Compound 11a) is an orally active activator for Keap1/Nrf2/HO-1 signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC50 of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model[1].
Target Antigen
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-18.html
Smiles
CN(C(C1=NN(C(C(C)(C)C)=C1)C2=CC=C(C=C2)F)=O)/C=C\C3=CC=CC=C3
Molecular Weight
377.45
References & Citations
[1]Zhang G, et al., Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury. Eur J Med Chem. 2025 Jan 15;282:117068.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168709/Nrf2-activator-18-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168709/
Clinical Information
No Development Reported
Curated Selection
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