Nrf2 activator 18
Nrf2 activator 18 (Compound 11a) is an orally active activator for Keap1/Nrf2/HO-1 signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC50 of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model[1].
Product Specifications
UNSPSC
12352101
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-18.html
Smiles
CN(C(C1=NN(C(C(C)(C)C)=C1)C2=CC=C(C=C2)F)=O)/C=C\C3=CC=CC=C3
Molecular Formula
C23H24FN3O
Molecular Weight
377.45
References & Citations
[1]Zhang G, et al., Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury. Eur J Med Chem. 2025 Jan 15;282:117068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FHB86921 100 Tests
Anti-Human EGFR/ERBB1/HER1 Antibody (E7.6.3), FITC
Sign In for Pricing
View Details